Hydrophilic vs Lipophilic Statin Therapy in Mild Cognitive Impairment

 
   Lead Investigator:    Christian Bergman
   Institution      :    EVMS
   E-Mail           :    Carl.Bergman@vcuhealth.org
   Proposal ID      :    817


   Publications:


1  Bergman C, Hilliard DD, Cunningham TD, Okhravi HR
   Association of Statin Use and Statin Type on Cognitive Decline in Older Adults with Normal Cognition or Mild Cognitive Impairment: A 4-Year Analysis
   2018   Journal Article  JAMA Neurol , 

   SUBMITTED





   Proposal Description:
   Our aim is to use the UDS database to develop a retrospective cohort analysis     that will seek to ascertain the effect of statin therapy on cognitive             performance, as well as to examine the potential ability of lipophilic statin     therapy to delay cognitive decline in elderly patients.                           1) In elderly adults with baseline normal cognition, does lipophilic statin       therapy slow down the progression to mild cognitive impairment (MCI)?             2) In elderly patients with baseline MCI, is there a slower rate of cognitive     decline among patients treated with lipophilic statin therapy?